Surprised no one has mentioned anything involving sustainable/clean tech (energy, food, water, materials). This site does stress existential threats, and I'd think that, given many (most?) societal collapses in the past were precipitated, at least partly, by resource collapse, I'd want to concentrate much of the startup activity around trying to disrupt our short-term wasteful systems. Large pushes to innovate and disrupt the big four (energy, food, water, materials) would do more than anything I can think of to improve the condition of our world and minimize the major risks confronting us within the next 100 years (or sooner).
It's not as hopeless as it appears on first glance. Population growth will reach about 9-10 billion people within 50 years (not much more do to lower birth rates as developing countries have less children and developed countries go into negative population growth) so that is the carrying capacity to aim for. Decoupling the big four from the unpredictability of scarcity, monocrops, climate change, and depletion/destruction by not only using innovations in the specific domains, but using advanced information technologies and algorithms (operations research, stigmergic routing, ..) would be the first time our planet is placed on a secure and sustainable foundation for our basic resource needs. If there is any other large, audacious goal that would change the world positively more than this (other than a positive singularity) I can't think of it.
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From what I've read of the source writings within the contemplative traditions, modern neuroscience studies and theories on meditation, and my own experiences and thoughts on the subject as well, I've come to view the practice of meditation as serving 3 different but interconnected purposes: 1.) ego loss, 2.) cultivation of compassion, and 3.) experience of non-dual reality.
Ego loss means inhibiting or eliminating the internal self-critic by changing the way you perceive the target of that critic, namely the concept of a stable 'self' that you identify with. Suffering is caused by the struggle of attachment, which is a manifestation of your internal self-critic admonishing your identified 'self' over future desires and past failures. By changing the concept you identify with as your 'self', you remove the object or target of the self-critical process and it fades away, allowing you to be free to live in the moment unhindered by such suffering. Meditation lessens the activation of what is called the default mode network, a network of neurons that extend through several anatomical brain regions and which the over-activation of is implicated in many mood disorders including anxiety, depression, ocd, among others.
Cultivating compassion, generally seen as a way to put yourself in another's shoes and wish others to be free from suffering and attain happiness, is also a way to achieve those things for your self as well. Compassion, once cultivated, recursively extends back onto yourself also, and allows you to be compassionate about your own life. Being loving and kind to yourself, not in a narcissistic way, but in an egoless, purely compassionate way as a sentient being among others, helps you remain in a positive mood and help others to do the same. Mirror neurons and the ability to form a theory of mind are hypothesized to be active in empathic cognition, but they may also prove to be the crucial substructure that allows us to have a theory of our own minds, the seat of the 'self' if you like, and so compassion is both an outward an inward directed process.
Lastly, experience of non-dual awareness is somewhat like the combination of the previous two effects, but taken further it inculcates a deep connection between you, others, and everything else in the universe as one unseparated whole. I've only experienced this sensation twice, but it is overwhelming and life changing.
In conclusion, meditation helps to develop and sustain these brain processes, but it is not easy, takes a lot of time, and may not even be effective for many people. I'm hoping that affective neuroscience and neurotechnology will progress to the level where meditation is unnecessary for achieving these states (though can and should be practiced for aesthetic reasons for those so inclined).