This doesn't require omniscience, or AI: people do this now (based on info they have). If you have more info, we know how to use it (there is theory). Why are we talking about AI, this is a math problem.
Slightly harshly worded suggestion (not to you specifically): maybe more reading, less invocation of robo-Jesus in vain.
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The randomized control trial is a great example where a superintelligence actually could do better by using a non-random strategy. Ideally, an AI could take its whole prior into account and do a value of information calculation. Even if it had no useful prior, that would just mean that any method of choosing is equally "random" under the the AI's knowledge.
I'm going to commit a social faux pas and respond to my own comment, because multiple subthreads are all saying essentially the same thing: this is just math, the theory is known, humans can already do it (often with some help from computers to get through the math).
As I've read it, one of the major takeaways of lesswrong is that AI is not magical. If humans cannot possibly figure out the theory, neither can an AI. If humans cannot possibly do the math (possibly with some help from a computer), neither can an AI. Anything an AI can do, a human can also do in principle. They differ only in the degree: AIs will eventually be able to do much more complicated math, solve much more complicated problems, and self-improve much faster and more reliably.
So if you look at my original suggestion and think "that's nothing special, a human can do that in theory" then you're completely correct. Things humans can do IN THEORY are EXACTLY the things with which an AI can help.