Comment author: maxmore 25 April 2013 05:44:22AM 3 points [-]

Don't hesitate to let me know if I or Alcor's membership administrator Diane Cremeens <diane@alcor.org> can help by answering any questions. You can reach me at <max@alcor.org>

Comment author: benbest 13 April 2012 09:23:56PM 0 points [-]

Any funeral director can move your body. Most CI patients are shipped in ice or dry ice by funeral directors. Contracting with Suspended Animation for SST (Standby/Stabilization/Transport) can minimize ischemic damage. Three-quarters of CI Members with contracts and funding for cryopreservation have not opted for SA. Most people do not die unexpectedly, but for those who do neither Alcor nor SA will be of much help in the ischemic damage produced in those cases. SST is not available from Alcor or SA outside of North America, at present.

Comment author: maxmore 04 May 2012 05:36:10AM 0 points [-]

The last statement is not accurate. Currently, with some warning, Alcor WILL deploy people outside of North America. In the near future, we expect to be able to deploy more local responders either instead of or in addition to our own personnel.

Comment author: Eliezer_Yudkowsky 18 April 2012 02:46:39AM 3 points [-]

Indeed, I'm young and not yet rich. If I was rich, though, given my prior state of knowledge I would've gone with SA + CI on the belief that CI seemed more long-run stable - CI seems more risk-averse and more financially prudent. I've updated somewhat on the financial prudence of Alcor as a result of reading these threads, and if the decision suddenly mattered for some reason, I would now require more investigation to figure out whether SA + CI or Alcor was the better long-run bet.

Comment author: maxmore 04 May 2012 05:27:42AM 2 points [-]

Depends what you mean by risk-averse. Alcor has an unquestionable history of fighting for its members' wishes, rather than giving up on them at the mere hint of a legal battle. The only way in which CI could be said to be more financially prudent (but in a way with its own costs) is in its remarkable ability to hold down operating costs. I'm working hard on reducing our costs without undesirable penalties in terms of capabilities. I think we are also now at a point where further membership growth will yield significant economies of scale.

But take a look at both organizations' financial statements. You will see that CI expects to maintain patients indefinitely -- and revive them -- on a small amount of per-patient funding. That takes some heroic and highly risky assumptions to accept. Alcor has carefully structured institutions and policies to manage sustainably for the long-term, including strict limits on what can be charged to the patient care trust fund, a 2% draw on the Endowment Fund, and an investment policy that has been giving us gains (while CI has been losing on its investments). If you continue to delve into the gory details, I think you may continue to update your views further.

Comment author: benbest 13 April 2012 01:18:56PM *  3 points [-]

It is odd that Max would criticize CI for only perfusing the head in light of the fact that the great majority of Alcor patients are neuros (head-only). The head and the brain are the most important part. CI will perfuse the body with glycerol for CI Members who request it, but CI does not do this unless requested. Look at CI's Perfusion Preference document, which all CI Members have the option of completing when making cryopreservation arrangements: http://cryonics.org/documents/Perfusion_Preference.html . When the majority of Alcor Members opt for neuro, why rag on CI about the fact that the majority of CI Members opt for no body perfusion (or opt by default)?

In any case, vitrification of the body is not possible either at Alcor or CI at present. CI's vitrification solution can eliminate brain ice formation and even demonstrably results in hippocampal slice viability when cooled to -130Celsius and rewarmed, and is vastly less expensive than M22. I doubt that the extra expense of M22 is worth the difference. I do believe that it is important to make cryonics affordable, and I am pleased to be offering a lower cost alternative. Standby/Stabliization/Transport (SST) from Suspended Animation is an optional extra for CI Members, but SST is mandatory for Alcor Members. Only about a quarter of CI Members with cryopreservation arrangements have chosen to have SST from SA (I have chosen that option). I am proud that the comparisons page at CI does not involve a lot of breast-beating, but only contains objective information http://cryonics.org/comparisons.html .

Comment author: maxmore 04 May 2012 05:07:30AM 0 points [-]

Ben: I wasn't actually criticizing CI for not perfusing the body other than the brain, I was simply pointing it out. CI members in general seem very insistent on the importance of cryopreserving their entire body. Given THAT, it seems important to note that their body will not be cryoprotected. However, thanks for pointing out that CI will do so if requested. How often is that request made?

Why do you say that vitrification of the body is not possible "either at Alcor or CI"? It is done at Alcor for whole body members.

Comment author: wedrifid 09 April 2012 09:08:00PM 8 points [-]

the board have frequently pushed to add more to the Endowment Fund even where it could legitimately be put into operations.

By 'pushed to add' do you mean took actions that actually resulted in adding or that they made a noble effort?

Comment author: maxmore 12 April 2012 06:09:24PM 3 points [-]

I mean that when we received some income that was not definitely specified for a particular purpose, when I suggested that some of it go to operations, the board unanimously insisted it all go into the Endowment Fund.

Comment author: mikedarwin 12 April 2012 04:51:45AM *  5 points [-]

Brian, when you say: "Mike, let's be fair about this. Veterinary surgeons for thoracic surgery (after loss of Jerry Leaf) and chemists for running perfusion machines were also used during your tenure managing biomedical affairs at Alcor two decades ago. You trained and utilized lay people to do all kinds procedures that would ordinarily be done by medical or paramedical professionals, including establishing airways, mechanical circulation, and I.V. administration of fluids and medications. Manuals provided to lay students even included directions for doing femoral cutdown surgery," you are either not reading what I wrote or are not being fair yourself. I not only acknowledge that this was so, I go so far as to say it is completely acceptable with the caveat that such people are instructed, vetted and mentored properly. I'll go even further (as I have repeatedly, elsewhere) and state that the most highly qualified medical personnel can be dangerous, or even worse than useless unless they have been trained and mentored in human cryopreservation as a specialty. There's nothing remarkable about this; no reasonable person would want a psychiatrist or a dermatologist doing bowel or brain surgery.

Some of the same people who performed very well in the past, and who are not medically qualified, are still at Alcor. The individual people, per se (in this instance), are not the problem. Rather, it's the absence of the paradigm of cryonics as a professional medical undertaking that's missing. The evidence for that is present in Alcor's own case histories where highly qualified medical personnel do things like discontinue cardiopulmonary support on still warm patients in order to open their chests for cannulation (http://alcor.org/Library/pdfs/casereportA2435.pdf) or drill burr holes without irrigating the drilling site with chilled fluid to prevent regional heating of the brain under the burr. We are in complete agreement on these issues, as far as I can tell. Where we apparently differ is on how to resolve them.

The most interesting thing to me about this post from Brian is information it communicates for the first time. I follow Alcor's announcements, read its magazine and track its public blog, as I necessarily must, so I am surprised to learn that "In Alcor's O.R., Alcor is presently evaluating and training two board certified general surgeons to supplement the veterinary surgeon and neurosurgeon who have been used by Alcor for the past 15 years." This is the kind of information that I would expect to see showcased in the organization's literature and on its website, not disclosed here. This is the kind of thing that happens over and over and which degrades member confidence in the transparency of the organization. The next question is, who what, where and how? What are the details of this training? What kind of model is being used? What are the results to date?

Yes, SA does use pigs for training, but they use them in a non-survival mode - they get no robust feedback about errors, and no new insights. In fact, Brian might have mentioned that Alcor has used both animals and human cadavers in this manner, but I think he understood that the point I was making was about vetting your skills in an outcome driven fashion. That is not being done.

What's even more disturbing is that there is virtually no visibility into the outcome from even these training operations. SA and Alcor are both essentially black boxes - there is no data, no performance reports, not even any reports or internal scoring of how well simulated cases proceeded. There's at least one reason for this, and that is that there is no scoring system, internal or external. When things go wrong, well, it's oops, we shouldn't do that next time. And if that isn't the case, then I'd love to hear it and I want to see the data to document it. That is an eminently reasonable request.

It's great that Alcor can sometimes mount skilled perfusionists and highly skilled emergency vascular surgeons. But that isn't the issue. The issue is the framework of knowledge, understanding and consistent performance that is absent. A surgeon or a perfusionist are, absent mentoring (internship), TOOLS to be used by and within that framework. If a man tells me he has the best glass cutting tool money can buy, but he doesn't know how to cut glass, well, I'm going to be underwhelmed.

Alcor patient case reports are disorganized, inconsistent and erratic narratives that make objective evaluation impossible. No great genius is required to consistently collect and organize the key data that define how well a case went - or didn't. The first cryonics case report was done by a 17 year old and a 22 year old graduate student:

http://www.lifepact.com/images/MTRV3N1.pdf

Examples of competently executed cases and case reports are available on Alcor's own web site and the data captured, reduced and presented in these case reports was achieved using a tiny fraction of the financial and personnel resources Alcor currently has available:

http://www.alcor.org/Library/html/casereport8511.html

http://alcor.org/Library/html/fried.html

http://alcor.org/Library/html/casereportC2150.htm

http://alcor.org/Library/html/casereport8504.html

LOOK AT THESE CARE REPORTS CAREFULLY and then look at those on the Alcor website from 1997 forward: http://www.alcor.org/Library/index.html#casereports

I'm not trying to be contrary, difficult, or unreasonable. What I am asking for is core competence, not perfection. There is nothing either exotic or impossible in that. For example, Alcor has a Novametrix CO2SMO capnograph and respiratory function analyzer. The device can effortlessly capture and write to disk over 60 different respiratory parameters and it measures the end-tidal expired carbon dioxide (EtCO2) in the patient's breath. The EtCO2 is the gold standard for determining how effective cardiopulmonary support (CPS) is. And if CPS is not effective, than that is both additional ischemic time the patient is experiencing and it is an opportunity to intervene and fix the situation. Or at worst, it offers the possibility of learning what caused inadequate CPS so that it might be avoided next time. The only skill required to use the device is to put the walnut sized sensor in line between the patient's airway and the ventilator on the LUCAS CPR machine: http://frankshospitalworkshop.com/equipment/documents/pulse_oximeter/user_manuals/Novametrix_8100_-_User_manual.pdf That should make it easily possible to produce graphic data like this:

http://i293.photobucket.com/albums/mm55/mikedarwin1967/EtCO2inCPSgraph.png

THAT kind of data speaks definitively to how that patient was stabilized and transported, and in aggregate it provides a statistical dataset that speaks to the overall performance of the organization. It should be accompanied with graphic data for the patient's TEMPERATURE, mean arterial pressure (until the time of arrest), the SpO2 (pulse ox) and other relevant data. This was done in the past by stressed out, sleep deprived, mostly volunteer people who were trained in-house. If that kind of data collection and accountability are considered "perfectionist," or some kind of golden past no longer to be achieved, then I restate my opinion that something is terribly wrong.

Paramedics are taught that the single most important and most critical indication of the efficacy, or lack thereof, of CPR is the EtCO2 of the patient over time. Where is this data???? This is only one of countless examples I could use - but it is especially relevant because it is simple data to collect, and I know from Alcor's recent case reports that they have a CO2SMO and they are actually using it on patients during the peri-arrest hospice period. Again, where is the data? That data is the ONLY way anyone has to evaluate the quality of cryonics cases because the patients cannot speak to us.

If you want to stop my criticisms, you need only show me the data and offer me and everyone else the opportunity to be reasonably certain it is valid and representative.

Comment author: maxmore 12 April 2012 05:59:20PM 2 points [-]

"I follow Alcor's announcements, read its magazine and track its public blog, as I necessarily must, so I am surprised to learn that "In Alcor's O.R., Alcor is presently evaluating and training two board certified general surgeons to supplement the veterinary surgeon and neurosurgeon who have been used by Alcor for the past 15 years." This is the kind of information that I would expect to see showcased in the organization's literature and on its website, not disclosed here. This is the kind of thing that happens over and over and which degrades member confidence in the transparency of the organization. "

In fact, I did mention the new surgeons, briefly, in an Alcor News post on April 2: http://www.alcor.org/blog/?p=2518 And similarly in the issue of Cryonics magazine now in production. Since we are just starting to work with these surgeons, it didn't yet seem appropriate to report much more. We are continually reporting on just about everything. Your attempt to cast Alcor as non-transparent should be obviously false to anyone who looks at what we communicate.

Comment author: [deleted] 09 April 2012 01:03:55PM 16 points [-]

the Board had decided to put the other $3.5M into an Endowment and withdraw only 2% per annum, or about $70,000 per year, for Alcor's operational needs.

Have they stuck to this plan, or has the piggy bank been smashed open?

In response to comment by [deleted] on Alcor vs. Cryonics Institute
Comment author: maxmore 09 April 2012 06:54:41PM 11 points [-]

Alcor has stuck to this plan. The board takes it very seriously. Not only have we not taken out more than 2% per year, the board have frequently pushed to add more to the Endowment Fund even where it could legitimately be put into operations.

In response to comment by [deleted] on Alcor vs. Cryonics Institute
Comment author: Jayson_Virissimo 09 April 2012 08:57:59AM *  8 points [-]

If Yudkowsky is signed up with C. I., then that is slight evidence that C. I. is superior to Alcor. This is so not because he is famous, but because he is more intelligent, rational, and informed than I am. Of course, if I actually studied cryonics in-depth, then my new knowledge would screen-off most of the evidential weight of the opinions of these "famous" people.

Comment author: maxmore 09 April 2012 09:14:45AM 13 points [-]

Consider that it might actually be evidence for a different conclusion: Eliezer signed up for cryonics some years ago, when he had little income, bravely foregoing well-paid employment in favor of pursuing his core goals. (I can relate to that!) I would very much like to talk to E.Y. about whether it's time to reconsider his past decision based on current information and current finances. I'm just an email or a phone call away, Eli...

Comment author: CharlesR 09 April 2012 06:55:30AM *  6 points [-]

maxmore, since you're here, I have a question:

How much life insurance do I need?

The cost for whole body is $200,000. So do I need $200,000 or do I need what it costs at time of death? Historical data says the cost doubles every 20 years.

Comment author: maxmore 09 April 2012 08:38:34AM *  18 points [-]

CharlesR: First of all, let me say that I have sufficient funding for whole body, yet I have chosen the neuro option. I find it difficult to fathom why anyone would want to bring along a broken-down old body which is going to have to be replaced anyway. We can store ten neuro patients for the cost of one whole body patient (which means that we are probably underpricing WBs currently). A neuro arrangement with Alcor currently costs $80,000. Although WB prices may have to rise before long, I've heard no suggestion that neuro rates need to rise anytime soon.

However, assuming someone is determined to take along their complete body, no matter how old and infirm, to answer your question: You CURRENTLY need a MINIMUM of $200,000. At that rate, we are currently drawing between 3% and 4% of the amount going into the Patient Care Trust for indefinite care and eventual revival. That may be sustainable, but is more than our desired conservative estimates. We aim to draw no more than 2% per year. Currently, I'm driving to reduce our costs, especially for liquid nitrogen. Early next year, we should be able to revise our contract and bring these down significantly.

Even so, you should plan to have available not $200,000, but that amount compounded by something like the general rate of inflation. (Your cost doubling rate of 20 years looks close to me. I think it's maybe 22 or 23 years, given a century-long average, but very close...) Unfortunately, some cryonicists have assumed that costs would remain unchanged. Given the history of inflation, that expectation is simply either ignorant or irrational. I would urge every cryonicist to plan for costs to rise by at least the historical long-run average of about 3% annually.

How do you plan for that? You might take out considerably more life insurance initially. You might take out the current minimum or a bit more, then over time supplement that by prepaying additional amounts. We are currently figuring out various options that might help deal with the annoying but inevitable reality of inflation.

If you, or anyone else, would like to discuss this in more detail and in a more personal way, please, please, please, call me at 480.905.1906 x113

--Max

Comment author: prespectiveCryonaut 09 April 2012 06:49:50AM *  3 points [-]

Thanks for your reply, Max. It does seem that Darwin is a bit harder on Alcor, but perhaps some of that is just because it's closer and more personal to him from having worked there and being signed up with them.

Comment author: maxmore 09 April 2012 08:23:39AM *  7 points [-]

Yes, exactly! Darwin says very little about CI. He's enormously critical of Alcor. Why? The answer is complicated, but part of it clearly is that he was a major force in Alcor in earlier years and has perfectionist standards that ignore costs and other real constraints. He may also be envious that he isn't running things. Alas, his past relationships make that inevitable.

Despite his impulse to stick in the knife, I keep a close eye on his detailed blog posts, since he does have a remarkable depth of knowledge. That depth and his most excellent writing skills often fool people into believing that his judgment is better than it is. But, flawed as it is, his writing contains much of value, so I set my feelings aside and glean as much value as I can from his views.

If Darwin were to turn his attention to CI, the result would be truly ugly!

Please note, that I'm GLAD that CI exists. I respect Ben Best. I think he's doing the best he can with what I think is a badly flawed approach. Although I worry about CI's future, anyone who wants to be cryopreserved but genuinely cannot afford Alcor (about the cost of a venti coffee at Starbucks daily) should definitely look to CI and an alternative.

--Max

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