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Comment author: morganism 03 January 2017 10:57:15PM *  0 points [-]

"The kind of reputation play exemplified by dares allows children to practice risk, negotiation, and social signaling. They define themselves and their groups through their speech acts and actions. Social standing and belonging have been so important to survival that they are worth risking death and injury in order to maintain."

"Dares, in other words, are a psychopath test. They allow the opportunity to scrutinize people’s displays of social emotions on demand, rather than having to wait for an aversive event to happen. "

[Link] Dares are social signaling at its purest

2 morganism 03 January 2017 10:48PM
Comment author: morganism 02 January 2017 10:26:36PM 0 points [-]
Comment author: morganism 29 December 2016 10:10:52PM 0 points [-]

"The newly discovered anti-CRISPR proteins—which are the first to work against the type of CRISPR-Cas9 system most commonly used by laboratories and the burgeoning gene editing industry—could help resolve both problems, Bondy-Denomy says, enabling more precise control in CRISPR applications but also providing a fail-safe to quickly block any potentially harmful uses of the technology."

link to Cell paper

Inhibition of CRISPR-Cas9 with Bacteriophage Proteins

www.cell.com/cell/abstract/S0092-8674(16)31683-X?

[Link] Off-switch for CRISPR-Cas9 gene editing system discovered

2 morganism 29 December 2016 10:08PM
Comment author: morganism 27 December 2016 11:41:51PM 2 points [-]

"Metformin lowers not only the blood glucose level, but also blocks the respiratory chain in the energy factories of the cell, the mitochondria. The antihypertensive drug syrosingopine inhibits, among other things, the degradation of sugars."

"And the effect was exclusively confined to cancer cells, as the blood cells from healthy donors were insensitive to the treatment."

Syrosingopine sensitizes cancer cells to killing by Metformin Science Advances, published online 23 December 2016 | DOI: 10.1126/sciadv.1601756

[Link] diabetes medication Metformin and hypertension drug syrosingopine treat cancers.

1 morganism 27 December 2016 11:39PM
Comment author: morganism 26 December 2016 08:47:29PM 1 point [-]

There was also a paper late 2015 that showed that the apicomplexans (toxo,malaria, chagas) were using the myelin sheath to get access to the brain and other major nerve bundles. There was another one that showed maltose or lactose could open the blood/brain barrier for up to 20 min., and there is some evidence that the plaques are actually to isolate and reduce the interference of the api spores that had burrowed into the nerve sheaths on the brain surfaces.

Comment author: morganism 26 December 2016 11:47:32PM 0 points [-]

And more on the BBB and the gut barrier.

the recent paper published by Maria Fiorentino and colleagues\

"After that little rant, the paper from Fiorentino is an interesting one in that the goal was to "investigate whether an altered BBB and gut permeability is part of the pathophysiology of ASD." To do this, tissue from both brain and gastrointestinal (GI) tract donated by a small number of deceased and non-deceased participants who were diagnosed with autism, schizophrenia or nothing related (not-autism controls) were analysed "for gene and protein expression profiles." This work was undertaken on the basis of "the interconnectivity of the gut–brain axis, [that] suggests that inappropriate antigen trafficking through an impaired intestinal barrier, followed by passage of antigens or activated immune complexes through a permissive blood–brain barrier (BBB), can be part of the chain of events leading to neuroinflammation and thereby subsequent disease." I might add that the use of the word 'disease' in that sentence is, I think, aiming to describe the physiological effects of 'leaky barriers' not the diagnosis of autism."

Comment author: morganism 26 December 2016 11:38:41PM 0 points [-]

a new study out based on the ProjectImplicit tests.

article first http://keenetrial.com/blog/2016/12/19/i-am-morally-superior-to-others-and-also-less-biased-than-everyone/

links at bottom are swamped with referrers

"While the agency and sociability traits were rated variably, almost all the participants rated themselves much higher on moral character than they rated the average person.

In an intriguing secondary finding, while the researchers found that overall self-esteem was not related to feelings of superiority, overall self-esteem was related to a sense of moral superiority."

[Link] 50 things I learned at NIPS AI and machine learning conference 2016

6 morganism 26 December 2016 08:50PM

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