Is the ultimate point of this set of posts this:
If you assume Omega has a probability δ of making an incorrect prediction, then your optimal strategy tends to one-boxing as δ tends to 0, therefore you should one-box in the original problem.
It seems like a lot of words to not quite come out and say that, though, so I'm probably missing something.
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Well, it does look that killing a big species is like freezing a body to absolute zero.
I am ready to buy that 0%-10% killers are distributed according to the promised power law, if you buy that reducing human population from X to kX costs -log k. Note that this doesn't alter your observed power law at all.
Why this? Because you have to be stronger than random resistances (due to genetics, lifestyle, health conditions etc.) present in different slices in populations.
Also, any virus will evolve while it infects a billion humans; there is a pressure to spread better and leave host alive.
And long incubation period cuts both ways — either you are stealth for years, or you are spread by air next week.