Many inflammatory pathways are tightly regulated, often because they involve chain reactions. Some of the PUFA metabolites, like 4HNE, can directly adduct to proteins and DNA. Considering we are systems meant to detect small amounts of damage in order to mount an inflammatory response, even the tiniest amount of some of those hydroperoxides can be problematic. Many of these molecules are reactive to UV light, and the most common report from the anti PUFA crowd is a complete stop to sunburns. Meaning people who used to burn within 10 minutes now require a few hours of direct exposure to get an inflammatory response. I can confirm this on myself (I live in the desert).
My interest in the this topic arose after a rather dramatic weight increase, insulin resistance increase, liver issues, kidney issues, all showed up when I was drafted into the IDF. The main change in my diet was seed oil, because I happened to consume very little of it or any other processed foods. Another change was an increase in sugar, but the health deterioration was rapid, and happened over about 2 months before getting discharged for the above health issues, which happened to reverse back at home.
My current vague working theory is that a combination...
You may be interested in the what Tucker Goodrich is doing, he's been reviewing the literature, and it's probably the Linoleic acid. He's pointed at the research on the direct stimulation of the endocanabinoid system by omega6. He's interviewed someone who studied Tributyl tin, an obesogen present at relevant doses in all of our environments, it also happens to agonize the same receptors omega6s do, and also has canabinoid activity.
Imagine trying to lose weight while smoking weed all day every day.
In Japan they use some Curcumin fructose beverage for hangovers. This guy made a video on it, check his sources if interested. https://www.youtube.com/watch?v=Ij_aJI5O9Rs
Ray Peat claims the Hayflick limit is nonsense, but... It's Ray Peat, so apply salt. http://raypeat.com/articles/articles/stemcells.shtml
Yeah, my argument, when taken that far, is unworkable. When considering how far to maximize the reward function, the metaphor of a treadmill is apt. There are forces constantly pulling backwards, and if I don't keep ahead of them, I might as well going backwards on my own. We take the conflict and complexity, and give it space. So I'd say "to remain conflicted is a kind of hypocrisy." or maybe to roll the dice at complexity and conflict isn't much better than pure hypocrisy. I'm having a bit of trouble phrasing this, I think because life isn't discrete lik...