All of Lev Protter's Comments + Replies

Many inflammatory pathways are tightly regulated, often because they involve chain reactions. Some of the PUFA metabolites, like 4HNE, can directly adduct to proteins and DNA. Considering we are systems meant to detect small amounts of damage in order to mount an inflammatory response, even the tiniest amount of some of those hydroperoxides can be problematic. Many of these molecules are reactive to UV light, and the most common report from the anti PUFA crowd is a complete stop to sunburns. Meaning people who used to burn within 10 minutes now require a few hours of direct exposure to get an inflammatory response. I can confirm this on myself (I live in the desert).

There is also a similar, lesser known "Israeli Paradox", where we consume less saturated fat and more unsaturated, and have worse cardiovascular stats.

My interest in the this topic arose after a rather dramatic weight increase, insulin resistance increase, liver issues, kidney issues, all showed up when I was drafted into the IDF. The main change in my diet was seed oil, because I happened to consume very little of it or any other processed foods. Another change was an increase in sugar, but the health deterioration was rapid, and happened over about 2 months before getting discharged for the above health issues, which happened to reverse back at home.

My current vague working theory is that a combination... (read more)

7ChristianKl
It seems like the US military would be the ideal institution to study this. They could effectively control the diets of soldiers, where diet control is usually a problem for most studies. Historically, the US military is also quite willing to fund research theses that mainstream academia despises like NLP's Fast Phobia cure helping soldiers with PTSD. 
2Slapstick
I'm not sure I understand why the experience you're describing gives an update towards these seed oil theories when it seems generally consistent with already understood health and nutrition knowledge. Is it particularly surprising that someone experiences some health problems after switching from a diet low in refined/processed ingredients to one high in those ingredients, while also undergoing the stress of being drafted into the military? (I would be very stressed though I shouldn't assume) Standard nutrition might be insufficient to explain the extent and speed at which the health issues occurred, but then likewise the seed oil theories would be insufficient to explain why more drafted soldiers aren't quickly developing those same health issues.

There's a pretty good reason old Hunter Gatherer types obsess about maternal diet before pregnancy. I also expect to find a much higher number of postpartum issues after non first born births. Basically blame nutritional deficiencies for this effect.

You may be interested in the what Tucker Goodrich is doing, he's been reviewing the literature, and it's probably the Linoleic acid. He's pointed at the research on the direct stimulation of the endocanabinoid system by omega6. He's interviewed someone who studied Tributyl tin, an obesogen present at relevant doses in all of our environments, it also happens to agonize the same receptors omega6s do, and also has canabinoid activity.

Imagine trying to lose weight while smoking weed all day every day.

In Japan they use some Curcumin fructose beverage for hangovers. This guy made a video on it, check his sources if interested. https://www.youtube.com/watch?v=Ij_aJI5O9Rs

2Maxwell Peterson
In Korea every convenience store sells “hangover preventative”, “hangover cure drink”, with pop idols on the label. Then you come back to America and the instant you say “hangover preventative”, people look at you crazy, like no such thing could possibly exist or help. I wonder how we got this way!

I read that Copper deficiency can impact Iron absorption (causing deficiency). Zinc supplementation can cause Copper Deficiency.

Ray Peat claims the Hayflick limit is nonsense, but... It's Ray Peat, so apply salt. http://raypeat.com/articles/articles/stemcells.shtml

2PhilJackson
There are papers showing senescent cells in humans with signs of shortened telomeres and replicative stress (e.g. [1,2]), so I wouldn't say the Hayflick limit is nonsense or irrelevant in humans. But there is perhaps a broader point that the Hayflick limit / telomere erosion has been over-hyped as the fundamental driver of ageing. Case in point, I once talked to a guy who told me "Immortality is impossible, because: telomeres".  The problem is that telomere erosion tells a simple and compelling story about what ageing is, like every cell has a built-in clock that prevents us living too long. From skimming the article, the point Ray Peat seems to be making, in a rather snarky and conspiratorial way, is that it's much more complicated than that, which is true. The point I'm making in this post is that there is no primary mechanism or process which is or causes ageing. Ageing is driven by a multitude of unavoidable cellular and molecular changes, but the list is finite, and fixing it is a tractable engineering problem.

How scientific is the idea that there is nothing but science to learn? Or perhaps one must reinvent the wheel to drive a car.

To me, the answer to any of such questions, is "name is name". A reference to a thing is that thing itself, yet simultaneously not that thing. It is also always empty, and unbound. Or we can keep arguing in absolutes, and be sure the answer is always past the horizon.

Yeah, my argument, when taken that far, is unworkable. When considering how far to maximize the reward function, the metaphor of a treadmill is apt. There are forces constantly pulling backwards, and if I don't keep ahead of them, I might as well going backwards on my own. We take the conflict and complexity, and give it space. So I'd say "to remain conflicted is a kind of hypocrisy." or maybe to roll the dice at complexity and conflict isn't much better than pure hypocrisy. I'm having a bit of trouble phrasing this, I think because life isn't discrete lik... (read more)