I'm a layman, but the "Hulk Sperm" method seems the most plausible EC-bypass method to me, and EC-bypass generally seems a more plausible route than EC-making. After reading the paper, it seems like any of the routes to EC-making seem either speculative, or very prone to failure (while also being hard to verify as a failure).
an issue with spermatogonial transplant into testicles is that GV (e.g. edited) spermatogonia are likely to be stressed and imperfectly maintained, and therefore are likely to be outcompeted by normal spermatogonia and die out
If...
"Hulk Sperm" method seems the most plausible EC-bypass method to me, and EC-bypass generally seems a more plausible route than EC-making
I partly agree, though with qualifications. One thing to note is that SSC methods are strictly haploid, hence half the power of diploid methods. Another thing to note is that SSC methods, especially ones that require iteration (editing), are not trivial in terms of EC; you have to maintain imprints, probably, as well as maintaining the general stem cell niche (i.e. ability to proliferate and ability to differentiate int...
Somewhat unrelated to the main point of your post, but; How close are you to solving the wanting-to-look-good problem?
I run a startup in a completely different industry, and we've invested significant resources in trying to get an LLM to interact with a customer, explain and make dynamic recommendations based on their preferences. This is a more high-touch business, so traditionally this was done by a human operator. The major problem we've encountered is that it's almost impossible to have an LLM to admit ignorance when it doesn't have the informati... (read more)