I think a lot of it has to do with your experience with computer based games and web applications.

This is why I say it would have to be a controlled study because those with significant computer experience and gaming experience have a distinct edge on those who do not. For example many gamers would automatically go to the WASD control pattern (which is what some first person shooting games use) on the "alternate control" level.

5:57:18 with 15 deaths here