Ander comments on The Amanda Knox Test: How an Hour on the Internet Beats a Year in the Courtroom - Less Wrong
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"Personally, I don't know the degree of likelihood of Knox's leaving no single piece of physical evidence when someone else left all kinds of traces. I do know the odds that I personally would change my story if police were investigating me for a murder in which I had no part: zero."
Maybe its true that you would never change your story to the police if you were being investigated for murder (can you be sure? Has this actually happened to you?) But even then, some people are innocent and yet change their story. (Also, lots of 'confessions' that are coerced out of people through interrogations are false).
Anyway, you can probably take the story-changing as weak evidence of guilt. However, compared to actual physical DNA evidence at the crime scene, which is STRONG evidence, this is nothing. Lets say you started out with a prior probability that Knox is guilty as being X (based on association with the victim), and then updated to be somewhat higher due to 'story changing'. But then when you consider the physical DNA evidence you have to MASSIVELY reduce the probability. The phyisical DNA evidence is orders of magnitude more important than various speculative psychological evidence about phone call lengths and story changing and things like that.
After correctly updating for all the evidence, you come to the conclusion that Guede has a very high probability of guilt, due to his actual DNA being at the crime scene, and Knox having a very low probability.
Given that we have a strong, scientific reason to believe that Guede was there, and Knox was not, you should convict Guede and acquit Knox. (Unless there is strong evidence that Knox had conspired to have Guede do the killing for her, which there is not).
Given that the murder can be fully explained by Guede's guilt, and that there is no strong evidence that Knox was also involved, there is no good reason to suspect Knox any more.