jimmy comments on Case study: Melatonin - Less Wrong

21 Post author: gwern 07 January 2010 06:24PM

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Comment author: jimmy 09 January 2010 07:39:59PM 0 points [-]

Thanks for the reply. I didn't mean to make you do the leg work for me.

But on the other hand, a regular Google search will turn up several people complaining of tolerance. (Whether you believe any of them or write them off as freaks, exaggerators, victims of fake melatonin, or whatever, is up to you.)

I think I'll believe them, but think they're taking too much. The metastudy I read a while ago (couldn't find it in a couple minutes, but I'll look harder if you want to see it) said that people were taking too much (>1mg) because there was a patent or something on using it at <1mg doses where it worked best. This led to people developing tolerances and the studies reflecting this. All the studies you listed were with lower doses of melatonin, so it makes sense that they didn't.

I guess I'll try taking it regularly now.