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gwern comments on Case study: Melatonin - Less Wrong
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I meant more in the way of clinical evidence, than anecdotes; I've never tried 100mg or heard of trying it before (my 1 9mg experience being sufficiently unpleasant to deter me from higher doses), so I guess I have to take your word for it on the claim of it not being incredibly disruptive.
You could take my word for it that large doses are not found to be incredibly disruptive (even in the long term) in clinical studies either.