I'm not convinced that concluding one is in a simulation is really the best bet here. A simulation would have a terrible amount of trouble specifying these effects. If for example, I have a simulation for say just our local system, how the heck are the people running the simulation easily going to be able to specify emotional states or the like? The only possible explanation I can have for this is that the simulation was originally started with humans having certain (simulated) brain structure and that structure is the type of structure that wizards have. Other humans can't do it because their structure isn't of the type the simulation recognizes to trigger magic.