MartinB comments on Open Thread, September, 2010-- part 2 - Less Wrong

3 Post author: NancyLebovitz 17 September 2010 01:44AM

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Comment author: jacob_cannell 22 September 2010 03:30:30AM 0 points [-]

So as an addendum to this, I found this blog which I am now reading as it has an updated view from the HIV skeptic position. Here is a post analyzing a recent study showing that cocaine can cause AIDS

CONCLUSION: Use of crack cocaine independently predicts AIDS-related mortality, immunologic and virologic markers of HIV-1 disease progression, and development of AIDS-defining illnesses among women

The 1st commenter had an inside view which I thought was especially interesting:

This certainly supports my eyewitness accounts of back in 1987 when several friends and acquaintances consciously or subconsciously decided that an HIV positive diagnosis surely meant death in 2 to 5 years, which led them onto severe crack and cocaine binges up until they were finally put on AZT monotherapy. Sad to say what the results were. Now they’re all part of the statistics. Can I say self-fulfilling prophecy?

Comment author: JoshuaZ 22 September 2010 03:43:01AM 2 points [-]

Cocaine is a drug that a) can damage the immune system and b) reduce appetite. It isn't at all unreasonable that HIV positive individuals who were heavy cocaine users would therefore progress to full AIDS faster than others. Note also that a 2-5 timespan isn't that far off from the timespan one would expect from HIV infection to emergence of AIDS given no treatment. Note that the study authors don't seem to think that this is at all unusual and nowhere do they claim that the use of crack cocaine was somehow causing AIDS.

Comment author: jacob_cannell 22 September 2010 04:04:02AM 0 points [-]

Sure, but it makes it more difficult to dissociate what the cocaine and virus are doing independent of each other, ie it makes it difficult to tease out the cause and effect from the correlation.

Comment author: JoshuaZ 22 September 2010 04:15:10AM 1 point [-]

Right, but that makes it just weak evidence. So it isn't very useful for the claim that cocaine somehow causes AIDS.

Comment author: jacob_cannell 22 September 2010 04:30:04AM *  0 points [-]

Well not quite, because cocaine was causing AIDs-like symptoms before HIV was presumed to be around, even if the great rise of cocaine use in the 80's in the west happens to correspond exactly with the rise of AIDS.

Comment author: Wei_Dai 22 September 2010 06:46:49AM 2 points [-]

the great rise of cocaine use in the 80's in the west happens to correspond exactly with the rise of AIDS

What's your source for this? Looking at the cocaine statistics and AIDS statistics myself, I'm not seeing this correspondence. What I do see is that cocaine use dropped to a fraction of its peak level by 1990, while AIDS kept rising.

Comment author: jacob_cannell 22 September 2010 12:43:24PM 0 points [-]

Just go down to the graph in your first link and look at the emergency room drug mentions and see the cocaine serge - it does indeed correspond to the AIDS epidemic. Deusberg's 2003 paper has more on this, but it's in the data you linked. From the emergency room data it looks like cocaine use was still growing up to 2001, but my point was with the rise. AIDS peaked in the mid 90's from your data link.