Will_Newsome comments on Open Thread September, Part 3 - Less Wrong
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The messed up sleep cycle part could have been coincidence: my sleep schedule is both chaotic and easily perturbed, such that random things can screw it up for days. But yeah, if you take it in the morning you should be fine. I mostly used it for staying up for 2 days in a row instead of 1, which I think is a nonstandard use case.