gwern comments on Rationality quotes: October 2010 - Less Wrong
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Well, now I have to link this DC: http://dresdencodak.com/2009/08/06/youre-a-good-man-charlie-darwin-2/
Not a surprise at all. Most major new paradigms have huge gaping flaws; this is one of the core theses of Paul Feyerabend's brand of philosophy of science in works like Against Method (eg. look at his analyses of major flaws in Galileo).