wedrifid comments on Efficient Charity: Do Unto Others... - Less Wrong
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Around 15 million pints of whole blood are donated per year in the US. At 3 lives per pint that comes out to 45 million. We can also assume that if lives per pint is 3 at the margin then the more efficient cases it will be even more than that. The population of the US just isn't high enough to account for that.
Oh, then there there is the fact that a lot of cases use a whole heap more than one pint of blood. (For example.)