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ciphergoth comments on Why *I* fail to act rationally - Less Wrong
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The research shows that not all of the efficacy of the drugs is down to the placebo effect.
Certainly drugs have effects. Whether the effects of the drugs are really a help is questionable.
There are a few conditions that people usually just can't cope with without drugs, even though the drugs have serious downsides. Lithium is a godsend for manic depression, despite it being quite dangerous - but considering how effectively repeatedly cycling is for people's lives, it's worth the risk.