handoflixue comments on Overcoming suffering: Emotional acceptance - Less Wrong
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For one, they report emotions simply not coming up anymore without having to apply any method. There doesn't seem to be an obvious way to undo that.
But more importantly, I strongly suspect it changes your values. Once you wirehead, you won't want to un-wirehead. (Though a benevolent mad neuroscientist might still 'save' you.)
blinks I've built emotions by observing that others have them and seeking to emulate it. The clearest example for me is that I didn't use to have any real empathy/sympathy responses - people's emotions were as meaningful to me as the state of a toy; it bothered me insomuch as it might mean my toy was broken, that's it. These days I have a fairly robust sense of empathy, but I can still turn it on and off fairly easily, and I don't let it interfere with exploration of more useful responses.
I've also done experiments with removing entire emotions for ~24 hours, setting specific external triggers that will snap me back (and making sure at least one person knows some of what I've done, so they can try to talk me out of it if I've accidentally wireheaded myself in to a state where I want to stay wireheaded)