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advancedatheist comments on How does long-term use of caffeine affect productivity? - Less Wrong
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Your genome may have something to do with caffeine's long-term effectis. According to 23andMe, I have a variant of the marker rs762551 which supposedly makes me a "fast caffeine metabolizer." Apparently the alleles for slow caffeine metabolism can increase your heart attack risk from drinking coffee.
Reference:
Coffee, CYP1A2 genotype, and risk of myocardial infarction.
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Search&db=pubmed&term=16522833