Your genome may have something to do with caffeine's long-term effectis. According to 23andMe, I have a variant of the marker rs762551 which supposedly makes me a "fast caffeine metabolizer." Apparently the alleles for slow caffeine metabolism can increase your heart attack risk from drinking coffee.
Reference:
Coffee, CYP1A2 genotype, and risk of myocardial infarction.
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Search&db=pubmed&term=16522833
I am trying to figure out whether caffeine helps productivity in the long run. Looking back 10 years from now, how much more/less productive will I have been if I were to drink coffee every day, or every second day?
Reviewing what has been written on the topic by our community so far: