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David_Gerard comments on Reply to Holden on The Singularity Institute - Less Wrong
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In general - never earmark donations. It's a stupendous pain in the arse to deal with. If you trust an organisation enough to donate to them, trust them enough to use the money for whatever they see a need for. Contrapositive: If you don't trust them enough to use the money for whatever they see a need for, don't donate to them.
I never have before but this CPA Audit seemed like a logical thing that would encourage my wealthy parents to donate :)