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hg00 comments on Welcome to Less Wrong! (5th thread, March 2013) - Less Wrong
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Comments (1750)
Welcome!
What was your dosage?
immediate dose : 200 mg modafinil + 800 mg piracetam around 10 am.
OD symptoms within 2/3 hours.
there was probably significant drug buildup of modafinil over the prior week i guess. was taking mostly 200mg (once 400 mg) a day the preceeding week. so i am guessing 300-500 mg built up.
effectively then
500 - 700 mg modafinil + 800mg piracetam.
resulted in 170/90 BP + 130-150 HR + severe anxiety for around 8-9 hours. ER docs didn't know what to do. I refused to get admitted to ICU.
Subsided by 10pm night. instigated a panic disorder and a drug phobia
cured by 25mg sertraline for 6 months. panic free (more or less) since.
has left me vigilant about drug interactions and adverse drug effects.
Thanks!
my experience could be useful to LWers experiementing with noo tropics in warning of the dangers of
a) drug interactions
there is need to be very careful while titrating doses up , especially when drugs are in combination. your body may manifest novel problems not seen by anyone else.
b) drug buildup :
need to be very careful while estimating effective doses to take drug buildup into account. even though superficially i was ingesting 200mg of modafinil, i was effectively on 500mg + of the drug.