A city of ~200,000 people if you include the outlying rural areas, in which you can go from the several block wide downtown to farmland in 4-5 miles in the proper directions. Fifteen minutes from another city of 60,000 which is very much a state college town. Forty minutes away from a city of nearly 500,000 people.

Granted the city of ~200,000 has a major university and a number of biotech companies.