My vague notion is that if your goals don't have ramifications in the realm of the normal, you're doing it wrong. If they do, and some aspect of your map upon which goals depend gets altered in a way that invalidates some of your goals, you can still look at the normal-realm ramifications and try to figure out if they are still things you want, and if so, what your goals are now in the new part of your map.
Keep in mind that your "map" here is not one fixed notion about the way the world works. It's a probability distribution over all the ways the world could work that are consistent with your knowledge and experience. In particular, if you're not sure whether "patternists" (whatever those are) are correct or not, this is a fact about your map that you can start coping with right now.
It might be that the Dark Lords of the Matrix are just messing with you, but really, the unknown unknowns would have to be quite extreme to totally upend your goal system.
In June 2012, Robin Hanson wrote a post promoting plastination as a superior to cryopreservation as an approach to preserving people for later uploading. His post included a paragraph which said:
This left me with the impression that the chances of the average cryopreserved person today of being later revived aren't great, even when you conditionalize on no existential catastrophe. More recently, I did a systematic read-through of the sequences for the first time (about a month 1/2 ago), and Eliezer's post You Only Live Twice convinced me to finally sign up for cryonics for three reasons:
I don't find that terribly encouraging. So now I'm back to being pessimistic about current cryopreservation techniques (though I'm still signing up for cryonics because the cost is low enough even given my current estimate of my chances). But I'd very much be curious to know if anyone knows what, say, Nick Bostrom or Anders Sandberg think about the issue. Anyone?
Edit: I'm aware of estimates given by LessWrong folks in the census of the chances of revival, but I don't know how much of that is people taking things like existential risk into account. There are lots of different ways you could arrive at a ~10% chance of revival overall:
is one way. But:
is a very similar conclusion from very different premises. Gwern has more on this sort of reasoning in Plastination versus cryonics, but I don't know who most of the people he links to are so I'm not sure whether to trust them. He does link to a breakdown of probabilities by Robin, but I don't fully understand the way Robin is breaking the issue down.