(2) is the interesting claim, though I'd hardly trust his word on (1) since I didn't see any especially alarming paragraphs in the actual paper referenced. I'm not an expert on that level of neurobiology (Anders Sandberg is, and he's signed up for cryonics), but I am not interested in hearing from anyone who has not demonstrated that they understand that we are talking about doing intelligent cryptography to a vitrified brain and potentially molecule-by-molecule analysis and reasoning, rather than, "Much cold. Very damage. Boo."
Unless someone spells out exactly what is supposed to destroy all cues of a piece of info, by explaining why two cognitively distinct start states end up looking like molecularly identical endstates up to thermal noise, so that we can directly evaluate the technical evidence for ourselves, all they're asking us to do is trust their authoritative summary of their intuitions; and you'd be just plain dumb to trust the authoritative summary of someone who didn't understand the original argument.
I'm trying not to be impatient here, but when I actually went to look at the cited paper and it said nothing at all about damage, it turned out this eminent authority's original argument consisted merely of, "To read off great synaptic info with current big clumsy microscopes and primitive imaging processing, we need big pressures. Look at this paper involving excellent info and big pressures. Cryonicists don't have big pressures. Therefore you're dead QED."
I suspect the basic underlying premise that causes this difference is that you believe that strongly superhuman AI will exist at the time of unfreezing, whereas most people either disbelieve that thesis or do not take it into account.
In June 2012, Robin Hanson wrote a post promoting plastination as a superior to cryopreservation as an approach to preserving people for later uploading. His post included a paragraph which said:
This left me with the impression that the chances of the average cryopreserved person today of being later revived aren't great, even when you conditionalize on no existential catastrophe. More recently, I did a systematic read-through of the sequences for the first time (about a month 1/2 ago), and Eliezer's post You Only Live Twice convinced me to finally sign up for cryonics for three reasons:
I don't find that terribly encouraging. So now I'm back to being pessimistic about current cryopreservation techniques (though I'm still signing up for cryonics because the cost is low enough even given my current estimate of my chances). But I'd very much be curious to know if anyone knows what, say, Nick Bostrom or Anders Sandberg think about the issue. Anyone?
Edit: I'm aware of estimates given by LessWrong folks in the census of the chances of revival, but I don't know how much of that is people taking things like existential risk into account. There are lots of different ways you could arrive at a ~10% chance of revival overall:
is one way. But:
is a very similar conclusion from very different premises. Gwern has more on this sort of reasoning in Plastination versus cryonics, but I don't know who most of the people he links to are so I'm not sure whether to trust them. He does link to a breakdown of probabilities by Robin, but I don't fully understand the way Robin is breaking the issue down.