Limitless deserves mention. It's a movie about a drug that makes people smarter.

When I first heard about it from MinibearRex, my initial reaction was "and, of course, the drug has some terrible drawback that causes the protagonist to lose in the end, because it's probably caveman science fiction." His response: "You really ought to see the movie." It is, in fact, not caveman science fiction, which alone seems like a worthwhile reason for rationalists (and futurists) to see it.