I guess that without proper social experiments it's hard to tell, but I feel that people rarely take the time to properly distinguish memeplexes based on their memetic content: they rely much more on things like faces, group associations, catchy names, etc. Monkey social stuff, you know.
I feel that you can either optimize for distinguished appearance, or arguing about the content of your memeplex of choice. I don't see the second working well to do the first job.