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I just downloaded the free Kindle version of Istvan's book, and it seems he's advocating a fusion of Objectivism/egoism and Transhumanism. Transhumanism and objectivism would seem to go together very naturally from a philosophical perspective, yet it seems to me that the great majority of transhumanists are left-liberals.
I watched the Joe Rogan interview with him where he disavowed his books political leanings. I'm a left-liberal who used to hate him because of his book, but after watching that interview I like him.
https://www.youtube.com/watch?v=9grWo5ZofmA