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LauralH comments on Harry Potter and the Methods of Rationality discussion thread, February 2015, chapter 108 - Less Wrong
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The Longbottoms were tortured into "insanity", but their canon appearance in St. Mungo's looks far more like brain damage from Cruciatus. And lots of Obliviates seem to cause brain damage as well. Breaking a FMC on Bertha Jorkins in book 4 ended up killing her.