zslastman comments on Whole genome sequencing vs SNP genotyping - Less Wrong

5 Post author: harcisis 11 June 2015 10:09PM

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Comment author: zslastman 17 June 2015 03:48:45PM *  1 point [-]

WGS is going to get cheaper and cheaper as time goes on, presumably in the future we'll have developed a process for analysing the results properly. In the intervening time, there isn't much to be gained from it. SNP genotyping gives you most of the info about common variants, because the things it doesn't catch (deletions, insertions, etc.) will generally have some SNP in linkage to them. The rare variants are what you miss, and right now we don't really know what to do with them.

In general I wouldn't overestimate how much genotyping will tell you. Your family history is likely to be more informative.