Gunnar_Zarncke comments on Open thread, Jul. 11 - Jul. 17, 2016 - Less Wrong
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There are long-term effects, but the impact seems to be not fully clear (wikipedia, On the other hand there are many known side-effects of the normal drugs used for the same purpose.
Beside the medical properties there are also the social properties of a drug.
See also the AMS report Brain science, addiction and drugs.