There is a lot of talk here about sophisticated rationality failures - priming, overconfidence, etc. etc. There is much less talk about what I think is the more common reason for people failing to act rationally in the real world - something that I think most people outside this community would agree is the most common rationality failure mode - acting emotionally (pjeby has just begun to discuss this, but I don't think it's the main thrust of his post...).
While there can be sound evolutionary reasons for having emotions (the thirst for revenge as a Doomsday Machine being the easiest to understand), and while we certainly don't want to succumb to the fallacy that rationalists are emotionless Spock-clones. I think overcoming (or at least being able to control) emotions would, for most people, be a more important first step to acting rationally than overcoming biases.
If I could avoid saying things I'll regret later when angry, avoid putting down colleagues through jealousy, avoid procrastinating because of laziness and avoid refusing to make correct decisions because of fear, I think this would do a lot more to make me into a winner than if I could figure out how to correctly calibrate my beliefs about trivia questions, or even get rid of my unwanted Implicit Associations.
So the question - do we have good techniques for preventing our emotions from making bad decisions for us? Something as simple as "count to ten before you say anything when angry" is useful if it works. Something as sophisticated as "become a Zen Master" is probably unattainable, but might at least point us in the right direction - and then there's everything in between.
Certainly drugs have effects. Whether the effects of the drugs are really a help is questionable.
There are a few conditions that people usually just can't cope with without drugs, even though the drugs have serious downsides. Lithium is a godsend for manic depression, despite it being quite dangerous - but considering how effectively repeatedly cycling is for people's lives, it's worth the risk.