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I have a hypothesis based on systems theory, but I don't know how much sense it makes.
A system can only simulate a less complex system, not one at least as complex as itself. Therefore, human neurologists will never come up with a complete theory of the human mind, because they'll not be able to think of it, i.e. the human brain cannot contain a complete model of itself. Even if collectively they get to understand all the parts, no single brain will be able to see the complete picture.
Am I missing some crucial detail?
Unless from the beginning you create the system to accomplish a certain number of tasks and then work to create the system to complete them. That can mean creating systems and subroutines in order to accomplish a larger goal. Take stocking a store for example:
There are a few tasks to consider:
A large store like Target has 8 different, loosely connected teams that accomplish these tasks. That is a store system within a building of 8 different subroutines to create a system th... (read more)