Gunnar_Zarncke comments on Open thread, Oct. 6 - Oct. 12, 2014 - Less Wrong Discussion
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The fact that the average effect size in a population of an intervention is small doesn't mean that there aren't individual members in that population that benefit a great deal.
Over time I also think of mood as less of a one dimensional thing. People often change the way they judge their happiness, so you don't have a constant standard.
Getting compliance is really hard.