Are there any lesser cultural or technological trends that, if they panned out, you expect might have just as great an impact as the greater trends you've just mentioned above?

I'm sure there must be. That was just a list of what immediately came to mind, with a catchall at the end. The Great Stagnation? Dysgenic breeding patterns? Malthusian limitations closing in? Genetically modified humans? Rationalism going viral? ("There is no God but Bayes and Eliezer is His prophet.") Rationalism going viral differently? ("Neuroscience proves that you do not exist. I do not exist. Even Eliezer does not exist. Room 101 exists.")