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Lumifer comments on Immortality: A Practical Guide - Less Wrong Discussion
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That's a pretty silly way to look at this trade-off. The choice is not between giving up something and dying. The choice is between (slightly) changing the enjoyment you get out of life and (slightly) changing the distribution of your life expectancy and/or what you will die of.
There are a lot of choices like that and different people make different choices.
The goal of the post in question was to live long enough to the point where medicine lets one reach actuarial escape velocity yes?
What I am quibbling with is your certainty about what will or will not "substantially impact how much enjoyment most people get out of life".