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jacob_cannell comments on Open Thread, May 11 - May 17, 2015 - Less Wrong Discussion
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Sure, all of that is true, but of the brain's 10 watt budget, more than half is spent on electric signaling and computation, so all the other stuff you mention at most increases the intrinsic simulation complexity by a factor of 2.
Are you aware of the complexity of folding of a single protein? It might not take much energy but it's very complex.
If you have 1000 different types of proteins swimming around in a neurons that interact with each other I don't think you get that by adding a factor of two.