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Clarity comments on Open Thread, Jun. 15 - Jun. 21, 2015 - Less Wrong Discussion
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Falciparum (the bad kind) only crossed into humans 5000 years ago (historical time!). But it used to be worse, before the evolution of sickle cell and other defenses (O+ Duffy negative blood, I think). Vivax crossed into humans 35 kya and was probably as bad or worse than falciparum before it evolved to be less virulent.