I think civilisation is in danger even disregarding the Fermi paradox.

There's no need to wait five years to start a transhumanist dating service. Suppose you want to have genetically enhanced kids in ten years time, presumably you would still want to date now. If you are looking for a long-term relationship now, then you would want it to be with someone you could have kids with one day.

The biggest problem is that transhumanists are mostly male. I wonder if this will change, given that transhumanism is becoming increasingly mainstream?