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ChristianKl comments on Open Thread, January 4-10, 2016 - Less Wrong Discussion
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People in the studies presumably don't take it all in the morning. Do you have an estimate of how that affects the total effect? How much bigger would you estimate the effect to be when people take it in the morning?
I take it in the morning just because I found that taking it late at night harmed my sleep. I have no idea how much people taking it later in the day might reduce benefits by damaging sleep; I would guess that the elderly people usually enrolled in these trials would be taking it as part of their breakfast regimen of pills/prescriptions and so the underestimate of benefits is not that serious.
D is a fat-soluble vitamin that the body can store. It's not like, say, the B vitamins which get washed out of your body pretty quickly. I don't think when you take it makes any difference (though you might want to take it together with food that contains fat for better absorption).
Multiple people such as gwern and Seth Roberts found that the timing makes a difference for them.
That's true.
What I meant is that blood levels of vitamin D are fairly stable and for the purposes of reduction in mortality it shouldn't matter when in the day do you take it. However side-effects, e.g. affecting sleep, are possible and may be a good reason to take it at particular times.
I don't think it's clear at all the the purpose of the reduction of mortality is different than the purpose of sleep quality.
Vitamin D does do different things but I would estimate that a lot of the reduction of mortality is due to having a better immune system. Sleeping badly means a worse immune system.