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Comment author: maxikov 07 April 2015 10:59:03PM *  10 points [-]

It seems like the approach of cooling the organism to -30C at 350MPa, and then raising pressure further to ~600Mps to freeze it could actually solve that. As far as I understand, the speed of diffusion in water it far slower that the speed of sound (speed of sound at 25C is 1497 m/s, while diffusion coefficient for protons at 25C is 9.31e-5 cm^2/s, which corresponds to 1.4e-4 m/s - 8 orders of magnitude less), which is the speed of pressure gradient propagation. So if we use raising pressure as a way to initiate phase transition, it will occur nearly simultaneously everywhere, and the solutes won't have time to diffuse anywhere.

ETA: I just realized that since diffusion propagates according to inverse square law, while sound is linear, they should be compared to each other at the shortest distance possible. So I checked the time it takes for a proton to cover 0.1nm (hydrogen atom diameter) in water - 5.37e-13s, which gives us 186 m/s. It's far greater than the original number, but still an order of magnitude smaller than the speed of sound. And if we take 4nm (the thickness of a cell membrane) we have 8.59e-10s - only 4 m/s, so it decreases very quickly, and we're pretty much safe.

Comment author: Joshua_Blaine 08 April 2015 01:38:50AM *  9 points [-]

That's a very sound (pun partially intended) insight, and I don't immediately see a significant reason for why that shouldn't be the case.

However, humans aren't perfectly uniform spheres of water (to borrow from a common physics joke), so some concerns do still exist. Namely: Pressure might propagate through them less predictably/quickly than just water, and different areas of the body might begin freezing at different pressures/in different orders (which can, however, be countered by raising pressures quickly).

I have updated significantly in the direction of "This idea might actually be very valuable to cryonics proponents," for sure.

Comment author: Joshua_Blaine 07 April 2015 10:08:00PM *  18 points [-]

First off, I love that you're actively pursuing alternative methods of human preservation. That's awesome, and I hope you manage to find some useful ideas in your search. However, I fear that this approach in particular doesn't really solve the problem that cryoprotectants successfully do (toxicity briefly aside).

without cryoprotectants the water will expand upon freezing, and break the cells.

This line in particular is my biggest point of contention. I am by no means an expert in this field, and my understanding may be moot in this context, but the expansion of water-ice crystals isn't the central concern for frozen biological cells. A quickly found source claims that:

Since ice is essentially pure H2O, ice formation can increase the concentration of minerals in the remaining cytosol to a toxic level. The increased mineral concentration in the cytosol will cause water to be drawn in from the surrounding cells by osmosis, which can cause the cell to swell and burst.

Alcor's official FAQ also says that:

When tissue is slowly cooled, ice first forms between cells. The growing ice crystals increase the concentration of solutes in the remaining liquid around them, causing osmotic dehydration of cells.

Your method doesn't prevent the formation of ice crystals, it merely changes the structure of the crystals, and at what temperature they form, so I suspect harmful cell osmosis can still occur. Of course, I could be insufficiently understanding why ice crystals effect the mineral concentration of cytosol, or the order in which certain biological areas freeze under variable conditions, and your smaller ice/lower freezing temperature would successfully prevent this issue. I don't believe this is necessarily the case, given your explanation, but if anyone who's more studied in these fields could speak up, I'd be happy to defer to their expertise.

Comment author: Joshua_Blaine 28 October 2014 11:09:11PM 27 points [-]

The ritual has been completed. I await my karmic reword, as per tradition.

There was a lot of good variance in the calibration questions (for me), so nice job thinking of them! Gur ivqrb tnzr dhrfgvba va cnegvphyne fhecevfrq zr jura V ybbxrq hc gur nafjre, nf rira nf n uhtr Zvarpensg sna V unqa'g ernyvmrq vg orng bhg frpbaq cynpr ol 3 zvyyvba.

Also, in a fit of needless cleverness, I made my public key decryptable (by my private key) into a plaintext message that works as an extra layer of identification in the case that I win the money.

Comment author: [deleted] 10 October 2014 02:41:34PM 2 points [-]

What about alternate measures?

Binary comparisions like: "Would I rather: Experience the previous hour exactly as it occured a second time, or X for an hour?". Where X might be : sleep, or some reference experience.

The abscence of negative mood. This isn't the same as happiness, but something like boredom or anger could have a clearer floor, or lend itself to a "Present, a little, none" scale.

Or more specific questions. Here's a PDF of an adjective based scale. An idea is to pick out only those adjectives that you already expect to vary.

In response to comment by [deleted] on Happiness Logging: One Year In
Comment author: Joshua_Blaine 14 October 2014 09:09:09PM 0 points [-]

I think ordering/ranking experiences would be more successful (in general) than trying to just give them scores.

An example of such a system: Every ping asks you to briefly describe the previous hour, and then shows you a list of every other ping you've written for the last week/month or so. You then put the description wherever it fits in the list, above everything that was less fun to experience, and below everything that was more fun.

In this way it's very easy to notice happiness trends (whether or not you're getting happier or sadder over time) without worrying about associating the same activity with the same score, even if it's becoming less or more fun to do.

Comment author: DataPacRat 07 October 2014 07:25:18PM 15 points [-]

I've passed 200,000 words in the story I started writing at the end of May, and as far as I can tell, I'm still on track to keep writing daily and bring it to a finish, instead of just trailing off into... well... not. That's pretty close to four NaNoWriMos in a row, with more to come. And the next story I write will be that much better for the work I've done on this one; and if I can manage my motivation so as to keep it up, I just might be able to consider myself "a writer" instead of "someone who writes".

"On the mountains of truth you can never climb in vain: either you will reach a point higher up today, or you will be training your powers so that you will be able to climb higher tomorrow." -- Nietzsche

Tsuyoku naritai!

Comment author: Joshua_Blaine 07 October 2014 07:46:13PM 2 points [-]

Tsuyoku naritai indeed! I haven't been keeping up with the story since my original binge back when book 2 as still in-progress, and you've really been getting things done, wow. Keep it up!

Comment author: Joshua_Blaine 07 October 2014 07:07:57PM *  20 points [-]

To start off with something everyone here will be interested in, I've recently and finally finished the first part of my video version of The Useful Idea of Truth (LW post here, Youtube link here). It seems well liked, and I'm even wondering if I should've posted it to Main. To understand what finishing this project means to me may be hard, as it means a lot. I have learned a ton doing this, and am really happy with the final look. My previous video editing experience was basically putting still frames and videos in sequential order with a spoken voice overtop. I'm 18 years old. I'm 18 and inexperienced and I just made something that I consider on par with CGP Grey in production quality, and he's been making videos professionally for years. It's so great to look at one of my idols, say "I bet I could do that too," and then actually do it. There's a real-world benchmark for this skill I've never really done before, and I matched it. I'm developing as a person, learning and training new skills, and it's feeling great. Of course, at >80 hours for that 6 minute video, my production rate isn't so great, given I still have schooling and work to worry about. I'm sure I can optimize, slim down, and otherwise improve my workflow, and I'd love to just jump right into doing this full-time, cranking out LW videos every other week, but I can't. I've got a bit of a pipe dream, of course, that crowd-funding or an official sponsor could keep me going until Youtube add revenue/Subable/Patreon can support me, but I'm not confident there's room in people's budget for something like this work to become a priority for them.

Less of public interest, I have made a lot of progress with my schooling. This last spring I made an arrangement with my High school to do my Senior year somewhat differently than is standard. Thanks to advanced placement classes completed in previous years, I had only 3 credits needed to graduate, so I had the option to just do those 3 courses at my own pace, over the summer. 2 have been completed (yay me, I can self-motivate!) , and all I have left to finish is my English 12 class. 4 days ago, I buckled down and finished the 1st of the 4 papers I need to do. The reading needed for the others is getting done quickly, and I'm happy with what progress I have done already. I look forward finishing High School without having to actually go to school, and the validation of my previous feelings toward self-paced lessons is nice.

October 2014 Bragging thread.

7 Joshua_Blaine 07 October 2014 06:20PM

So, to quote myself all those months ago when I first had this idea (I haven't actually posted one of these since the original. funny how that happens):

In an attempt to encourage more people to actually do awesome things (a la instrumental rationality), I am proposing a new monthly thread (can be changed to bi-weekly, should that be demanded). Your job, should you choose to accept it, is to comment on this thread explaining the most awesome thing you've done this month. You may be as blatantly proud of you self as you feel. You may unabashedly consider yourself the coolest freaking person ever because of that awesome thing you're dying to tell everyone about. This is the place to do just that.

Remember, however, that this isn't any kind of progress thread. Nor is it any kind of proposal thread.This thread is solely for people to talk about the awesomest thing they've done all month. not will do. not are working onhave already done.This is to cultivate an environment of object level productivity rather than meta-productivity methods.

Anything not mentioned in a previous bragging thread is still fair game, even If it didn't actually happen in the last month.

So, what's the coolest thing you've done this month?

Comment author: Benito 05 October 2014 10:48:25AM *  2 points [-]

That's really great, and well done. I'm looking forward to the others, so I can send the complete set off to some of my friends - if I just send off this one, a few I know will say 'Yes Ben, the postmodernists are right."

Comment author: Joshua_Blaine 05 October 2014 08:36:31PM 2 points [-]

That's one of my larger concerns about this format, actually. Only watching one video, out of the context of the others, could be more harmful than good. Even videos that are more independently consumable than this one run into the problem that knowing about biases can hurt people.

However, I think (eventually) having a large bank of videos for viewers to binge on, and including links directly to related LW posts I haven't yet covered is a good enough band-aid to assuage that worry.

Comment author: Dustin 05 October 2014 01:51:14AM 2 points [-]

Do you have someone to help you for future videos? I mean, just one other person to help you would probably cut down on mistakes like misspellings quite a bit.

Comment author: Joshua_Blaine 05 October 2014 03:39:03AM 2 points [-]

I don't really, though I did show the video to a couple people while making it, at different in-progress points, but there was never the specific instruction to look for spelling errors. If there is anyone here interesting in joining such a group for official "proofreading" purposes, comment here or send me a PM. I'll get to organizing a mailing list/subreddit/something to suit the purpose.

Comment author: shminux 04 October 2014 11:59:34PM *  4 points [-]

It's a great idea and well executed, I hope you continue! (Even though I firmly disagree with the epistemology described in the post.) Please note that there are a few spelling mistakes (seperate, privilige), maybe you can fix those.

Comment author: Joshua_Blaine 05 October 2014 12:31:40AM *  1 point [-]

Thank you for the feedback! I do plan to make many more, but unfortunately, these videos will easily have 2 or more months between each other, unless I can get the income to support myself working on them near full time. This little project took >80 hours of work.

As of now, I don't plan to go back and fix small errors, like misspellings. It's possible, and I do apreciate you pointing them out where they exist, but it's a lot of trouble to do.

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