Thanks for the write-up, I recall a conversation introducing me to all these ideas in Berkeley last year and it's going to be very handy having a resource to point people at (and so I don't misremember details about things like the Yamanaka factors!).
Am I reading the current plan correctly such that the path is something like:
Get funding -> Continue R+D through primate trials -> Create an entity in a science-friendly, non-US state for human trials -> first rounds of Superbabies? That scenario seems like it would require a bunch of medical tourism, which I imagine is probably not off the table for people with the resources and mindset willing to participate in this.
I'm not sure that this mental line of defence would necessarily hold, us humans are easily manipulated by things that we know to be extremely simple agents that are definitely trying to manipulate us all the time: babies, puppies, kittens, etc.
This still holds true a significant amount of the time even if we pre-warn ourselves against the pending manipulation - there is a recurrent meme of, eg, dads in families not ostensibly not wanting a pet, only to relent when presented with one.
Dropping my plans of earning to give, which only really made sense before the recent flood of funding and the compression of timelines.
Increasing the amount of study I'm doing in Alignment and adjacent safety spaces. I have low confident I'll be able to help in any meaningful fashion given my native abilities and timelines, but not trying seems both foolish and psychologically damaging.
Reconsidering my plans to have children - it's more likely I'll spend time and resources on children already existing (or planned) inside my circle of caring.
Relatively small behavioural changes on your end may address some of the causes of these frustrations. It sounds like you might be overstocked with things of relatively low long-term utility, which is why it's hard to immediately pass them on. Have you scanned your spending patterns for hyperbolic discounting, for example?
Comics are a great example - if you have the willpower to hold off until you can but a TPB, they're cheaper, more economic, more durable, take up less storage space, and are much easier to pass on or pass around than individual comics. If you have friends who also enjoy comics, it's easier to pass around books of them than individual issues, and you can probably read a broader range. Alternately, if you find a way to read comics online or through an app, you can enjoy getting stories as they come out but through digital distribution instead of dead trees. If you're not collecting dead tree stories for long-term value, and don't re-read, then that may be a positive trade-off for you.
You're correct in that throwing things away is one of the least useful things you can do with them. Each low-utility spare object is probably not worth a huge effort in disposing of appropriately individually, so why trap yourself into that situation by virtue of your own lifestyle choices?
Do you have municipal recycling facilities or charities that you could donate things to?
For the entrepreneur - I'd pay some marginally low cost to have comics delivered from MrMind's house to mine once they're done with them :-)
You'd run into cognitive overhead limits. Manually reviewing other people's conversations can only really happen at 1:1 to 2:1 speeds. Summaries are much more efficient.
Plus, people behave very differently in radically observed environments. Panopticons were designed as part of a punishment system for a reason.