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Reminds me an episode of radiolab you could be interested in :

from what I remember, they talked about a pill that was implanted into the patient and would dissolve and release its content in presence of alcohol in the blood. The chemical reaction would cause incredibly bad pain. The patients were given a foretest of the reaction pill and were told that the real reaction with the entire pill would be X times more painful and they might not survive.

can't find the episode, but found an article which talks about it. Didn't read it but it mentions the episode

http://somatosphere.net/2011/give-me-fear.html/