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Vaughn Papenhausen5y30

Also, mods, how do I tag this as "coronavirus"? Or is that something the mods just do?

4jimrandomh5y

For now, mods do it. This will be expanded to all users and to a wider variety of tags when tagging leaves beta.

Vaughn Papenhausen5y10

Thanks

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8 Has the effectiveness of fever screening declined?

by Vaughn Papenhausen

27th Mar 2020

1 min read

1 9

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On March 6th, jimrandomh predicted that the effectiveness of fever-screening for coronavirus would decline, because the virus would evolve to produce fever later or not at all. Has this happened in countries that have been liberally applying fever-screening?

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Has the effectiveness of fever screening declined?

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Mar 28, 2020*

It was never effective, due to the long incubation period and wide dispersion in symptom severity from person to person.

There are few enough viral generations in this pandemic and few enough mutations in any given branch now and few enough fever screenings in their histories that there literally cannot have been a decline overall.

[-]dsj5y10

I don't understand why you say it was never effective. Certainly some infected have no symptoms, or no symptoms yet, or different symptoms, but fever is among the most common symptoms, and so it does catch a significant fraction of active infections.

3[anonymous]5y

By 'effective' I was going with 'reliably able to exclude infectious people'. There were fever-screeners in American airports who never caught anyone with a fever, but got infected by someone they screened without a fever. People seem to be infectious for days before they get a fever, and about a third of people probably never develop fevers in the first place. And this is a function of the particular individual infection, not 'strains' - there is not enough generations and selection and genetic diversity for the strains to be meaningfully different yet.

2dsj5y

But in the context of the question as to whether it might exert selective pressure, even a ~10% reduction in R₀ would be quite relevant, when compounded over one or two dozen generations of the virus.

2brianwang7125y

It's worth noting here that coronaviruses are less vulnerable to selective pressure than most RNA viruses given that that they unusually encode proofreading activity, limiting genetic diversity. This article ( https://www.sciencemag.org/news/2020/03/mutations-can-reveal-how-coronavirus-moves-they-re-easy-overinterpret# ) claims that SARS-CoV-2 accumulates 1-2 mutations per month (its genome has 30,000 bases), which is...enormously inadequate to make even the smallest dent anytime this year in the monumental task that is modulating host immunity to modify onset of fever.

2[anonymous]5y

You overestimate the rate of emergence of relevant mutations. In the explosive range-expansion phase most lineages have zero functional difference from each other and almost all expansion of particular lineages comes from chance invasions of large vulnerable populations. There is a reason that when a species suddenly has a range-expansion event, you actually see a relaxation of selection and a buildup of deleterious mutations...

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