So the jackpot in the Ohio lottery is around 25 million, and the chance of winning it is one in roughly 14 million, with tickets at 1 dollar a piece. It appears to me that roughly a quarter million tickets are sold each drawing; so, supposing you win, the probability of someone else also winning is 1 - (1 - 1/14e6)^{250000}=2%, which does not significantly reduce the expectation value of a ticket. So, unless I'm making a silly mistake somewhere, buying lottery tickets has positive expected value. (I find this counterintuitive; where are all the economists who should be picking up this free money? But I digress.)
I pointed this out to my wife, and said that it might be worth putting a dollar into it; and she very cogently asked, "Then why not make it 100 dollars?" Why not, indeed! Is there any sensible way of deciding how much to put into an option that has a positive expected value, but very low chance of payoff?
I went wandering around ohiolottery.com (For instance, http://www.ohiolottery.com/Games/DrawGames/Classic-Lotto#4) and found this out:
There are also payoffs below the jackpot level, so I'm confident there's a positive EV per ticket.
The question as to how many tickets to buy, assuming you can effectively do so, is "All of them." Buy each individual ticket, take your 14 million tickets, and probably profit. (Remember, the jackpot kick will include some fraction of your 14 million, also. Plus, you'll have all the side prizes.) In practice, unfortunately, this requires a method to buy them effectively, some armored cars, and a staff of people to do it right. Failure to purchase all tickets results in some drama, for sure.
The execution expenses and risk are troubling; if those could be effectively mitigated, it's a great investment.
Assuming you're a few million short of that, though, it's harder. I buy CA lottery tickets when EV>1.20 per $1 invested. I have no strong justification for that number.