Recently published article in Nature Methods on a new protocol for preserving mouse brains that allows the neurons to be traced across the entire brain, something that wasn't possible before. This is exciting because in as little as 3 years, the method could be extended to larger mammals (like humans), and pave the way for better neuroscience or even brain uploads. From the abstract:
Here we describe a preparation, BROPA (brain-wide reduced-osmium staining with pyrogallol-mediated amplification), that results in the preservation and staining of ultrastructural details throughout the brain at a resolution necessary for tracing neuronal processes and identifying synaptic contacts between them. Using serial block-face electron microscopy (SBEM), we tested human annotator ability to follow neural ‘wires’ reliably and over long distances as well as the ability to detect synaptic contacts. Our results suggest that the BROPA method can produce a preparation suitable for the reconstruction of neural circuits spanning an entire mouse brain
http://blog.brainpreservation.org/2015/04/27/shawn-mikula-on-brain-preservation-protocols/
Thank you for the thoughtful reply.
Aren't neurons special? At the very least, they're mysterious. We're far from understanding them as physico-chemical systems. I've had the same reaction and incredulity as you to the idea that interacting neurons can 'generate consciousness'. The thing is, we don't understand individual neurons. Yes, neurons compute. The brain computes. But so does every physical system we encounter. So why should computation be the defining feature of consciousness? It's not obvious to me. In the end, consciousness is still a mystery and machine functionalism requires a leap of faith that I'm not prepared to take without convincing evidence.
Yes, counterfactual dependencies appear necessary for simulating a brain (and other systems) but the causal structure of the simulated objects is not necessarily the same as the causal structure of the underlying physical system running the simulation, which is my objection to Turing machines and Von Neumann architectures.
it's an interesting thought, and I generally agree with this. The question seems to come down to defining causal structure. The problem is that the causal structure of the computer system running a simulation of an object does not appear anything like that of the object. A Turing machine running a human brain simulation appears to have a very different causal structure compared with the human brain.