Recently published article in Nature Methods on a new protocol for preserving mouse brains that allows the neurons to be traced across the entire brain, something that wasn't possible before. This is exciting because in as little as 3 years, the method could be extended to larger mammals (like humans), and pave the way for better neuroscience or even brain uploads. From the abstract:
Here we describe a preparation, BROPA (brain-wide reduced-osmium staining with pyrogallol-mediated amplification), that results in the preservation and staining of ultrastructural details throughout the brain at a resolution necessary for tracing neuronal processes and identifying synaptic contacts between them. Using serial block-face electron microscopy (SBEM), we tested human annotator ability to follow neural ‘wires’ reliably and over long distances as well as the ability to detect synaptic contacts. Our results suggest that the BROPA method can produce a preparation suitable for the reconstruction of neural circuits spanning an entire mouse brain
http://blog.brainpreservation.org/2015/04/27/shawn-mikula-on-brain-preservation-protocols/
Shawn Mikula here. Allow me to clear up the confusion that appears to have been caused by being quoted out of context. I clearly state in the part of my answer preceding the quoted text the following:
"2) assuming you can run accurate simulations of the mind based on these structural maps, are they conscious?".
So this is not a question of misunderstanding universal computation and whether a computer simulation can mimic, for practical purposes, the computations of the brain. I am already assuming the computer simulation is mimicking the brain's activity and computations. My point is that a computer works very differently from a brain which is evident in differences in its underlying causal structure. In other words, the coordinated activity of the binary logic gates underlying the computer running the simulation has a vastly different causal structure than the coordinated activity and massive parallelism of neurons in a brain.
The confusion appears to result from the fact that I'm not talking about the pseudo-causal structure of the modeling units comprising the simulation, but rather the causal structure of the underlying physical basis of the computer running the simulation.
Anyway, I hope this helps.
Thanks for replying ! Sorry if the bit I quoted was too short and over-simplified.
That does clarify things, although I'm having difficulty understanding what you mean by the phrase "causal structure". I take it you do not mean the physical shape or substance, because you say that a different computer architecture could potentially have the right causal structure.
And I take it you don't mean the cause and effect relationship between parts of the computer that are representing parts of the brain, because I think that can be put into one-to-one corr... (read more)