Summary: the problem with Pascal's Mugging arguments is that, intuitively, some probabilities are just too small to care about. There might be a principled reason for ignoring some probabilities, namely that they violate an implicit assumption behind expected utility theory. This suggests a possible approach for formally defining a "probability small enough to ignore", though there's still a bit of arbitrariness in it.
I don't think the consensus of physicists is good enough for you to place that much faith in it. As I understand modern day cosmology, the consensus view holds that universe once grew by a factor of 10^78 for no reason. Would you pass up a 1 penny to $10,000,000,000 bet that cosmologists of the future will believe creating 10^100 happy humans is physically possible?
I don't know :-(. Certainly I like physics as a darn good heuristic, but I don't think I should reject bets with super-exponentially good odd based on my understanding of physics. A few bits of information from an expert would be enough to convince me that I'm wrong about physics, and I don't think I should reject a bet with a payout better than 1 / the odds I will see those bits.