Open problems are clearly defined problems1 that have not been solved. In older fields, such as Mathematics, the list is rather intimidating. Rationality, on the other, seems to have no list.
While we have all of us here together to crunch on problems, let's shoot higher than trying to think of solutions and then finding problems that match the solution. What things are unsolved questions? Is it reasonable to assume those questions have concrete, absolute answers?
The catch is that these problems cannot be inherently fuzzy problems. "How do I become less wrong?" is not a problem that can be clearly defined. As such, it does not have a concrete, absolute answer. Does Rationality have a set of problems that can be clearly defined? If not, how do we work toward getting our problems clearly defined?
See also: Open problems at LW:Wiki
1: "Clearly defined" essentially means a formal, unambiguous definition. "Solving" such a problem would constitute a formal proof.
I suspect the answer is no, at least not the kind of formal languages that have been suggested so far. The problem is this: as soon as you define a formal language, I can say "the lexicographically first object which can't be described in less than a million bits in your language". Given the uniqueness of this object, why should it be a priori as unlikely as a random million-bit string?
Note that in general, this sort of specification is uncomputable. To find the lexicographically first object which can't be described in less than a million bits, we would have to make a list of all objects which can be described in less than a million bits (and return the first thing that's not on the list). But we don't know if our UTM will halt for any given string with less than a million bits, so we can never know if our list is complete.