I don't acknowledge an upload as "me" in any meaningful sense of the term; if I copied my brain to a computer and then my body was destroyed, I still think of that as death and would try to avoid it.
A thought struck me a few minutes ago that seems like it might get around that, though. Suppose that rather than copying my brain, I adjoined it to some external computer in a kind of reverse-Ebborian act; electrically connecting my synapses to a big block of computrons that I can consciously perform I/O to. Over the course of life and improved tech, that block expands until, as a percentage, most of my thought processes are going on in the machine-part of me. Eventually my meat brain dies -- but the silicon part of me lives on. I think I would probably still consider that "me" in a meaningful sense. Intuitively I feel like I should treat it as the equivalent of minor brain damage.
Obviously, one could shorten the period of dual-life arbitrarily and I can't point to a specific line where expanded-then-contracted-consciousness turns into copying-then-death. The line that immediately comes to mind is "whenever I start to feel like the technological expansion of my mind is no longer an external module, but the main component," but that feels like unjustified punting.
I'm curious what other people think, particularly those that share my position on destructive uploads.
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Edited to add:
Compare a destructive upload to non-destructive. Copy my mind to a machine non-destructively, and I still identify with meat-me. You could let machine-me run for a day, or a week, or a year, and only then kill off meat-me. I don't like that option and would be confused by someone who did. Destructive uploads feel like the limit of that case, where the time interval approaches zero and I am killed and copied in the same moment. As with the case outlined above, I don't see a crossed line where it stops being death and starts being transition.
An expand-contract with interval zero is effectively a destructive upload. So is a copy-kill with interval zero. So the two appear to be mirror images, with a discontinuity at the limit. Approach destructive uploads from the copy-then-kill side, and it feels clearly like death. Approach them from the expand-then-contract side, and it feels like continuous identity. Yet at the limit between them they turn into the same operation.
I find this an immensely valuable insight: continuity, or "haecceity", is the critical element of self which naive uploading scenarios dismiss. Our current rational situation of self as concept-in-brain has no need for continuity, which is counterintuitive.
We know a good deal about the universe, but we do not yet know it in its entirety. If there were an observer outside of physics, we might suspect they care great deal about continuity, or their laws might. Depending on your priors, and willingness to accept that current observational techniques cannot access all-that-there-is, it might be worth embedding some value to haecceity near your value of self.
Contrast grow-and-prune uploading with slice-and-scan uploading: the latter will be anathema to the vast majority of humanity; they may "get over it", but it'll be a long battle. And slice-and-scan will probably be much slower to market. Start with Glass and EEGs: we'll get there in our lifetime using grow-and-prune, and our AIs will grow up with mentors they can respect.