Jonah Lehrer wrote about the (surprising?) power of publication bias.
http://m.newyorker.com/reporting/2010/12/13/101213fa_fact_lehrer?currentPage=all
Cosma Shalizi (I think) said something, or pointed to something, about the null model of science - what science would look like if there were no actual effects, just statistical anomalies that look good at first. I can't find the reference, though.
Is it possible that there is too much science today?
I mean, in the raw-numbers sense of number of professional scientists and number of papers published. You could, conceivably, increase the volume of "science" without increasing its accuracy. How do we know we're not doing that?
To me it seems pretty obvious that we are doing that, and have been for many decades. But I suppose spelling out an argument for this conclusion suitable for a general audience would require bridging some significant inferential distances.